Abstract
The objective of present investigation is to investigate antidiarrheal potential of Adenanthera pavonina seed aqueous extract (APSAE) in experimental animals. The APSAE was administered orally to three groups of animals (six per group) in order to investigate activity against castor oil and magnesium sulphate-induced diarrhoea in rats. The effect of extract on gastrointestinal transit using charcoal and castor oil induced enteropooling was assessed using Loperamide 3mg/kg was used as reference standard. Oral administration of APSAE at doses 50,100 and 200 mg/kg exhibited dose-dependent significant (P<0.05) antidiarrheal potential against castor oil and magnesium sulphate-induced diarrhoea in rats. APSAE also produced significant (P<0.05) reduction in propulsive movement in castor oil-induced gastrointestinal transit using charcoal meal in rats when compared with reference standard Loperamide. These findings demonstrate that Adenanthera pavonina seed aqueous extract shows significant antidiarrhoeal potential, thus justifying its traditional use in diarrhoea.
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