Antidiabetic potential of the leaf extract of Centella asiatica in alloxaninduced diabetic rats

Aninda Kumar Nath,Md Zia Uddin,Mir Muhammad Nasir Uddin,Mycal Dutta,Talha Bin Emran

doi:10.3329/jujbs.v4i1.27785

Abstract

The study was designed to evaluate the glucose and cholesterol lowering effect of the aqueous extract of Centella asiatica leaf using the alloxan-induced diabetic rats and compared the activity with diabetic control and antidiabetic drug (Glibenclamide). Leaf extract (50 mg/kg) of C. asiatica and Glibenclamide were administered to normal and experimental diabetic rats for the duration of 10 days. In the alloxan-induced diabetic rat model, C. asiatica extract (50 mg/kg) significantly (p < 0.05) lowered the fasting blood glucose level as well as the total cholesterol level. Serum insulin levels were not stimulated in the animals treated with the extract. In addition, changes in body weight, serum lipid profiles and liver glycogen levels assessed in the extract treated diabetic rats were compared with diabetic control and normal animals. Significant results (p < 0.05) were observed in the estimated parameters. Surprisingly, body weight was increased significantly (p < 0.05) in the C. asiatica treated diabetic group. Phytochemical screening showed the presence of alkaloids, flavonoids, glycosides, steroids and tannins in significant amountsJahangirnagar University J. Biol. Sci. 4(1): 51-59, 2015 (June)

Highlights

Diabetes mellitus (DM) is a disease in which homeostasis of carbohydrate, protein and lipid metabolism is improperly regulated by hormone insulin resulting in elevation of fasting and postprandial blood glucose levels
It is known that there are two basic types of diabetes; type 1 or insulin dependent diabetes mellitus (IDDM) characterized by a deficiency of insulin and type 2 diabetes or non insulin dependent diabetes mellitus (NIDDM) which is due to insulin resistance or reduced insulin sensitivity
Development of diabetes: Alloxan was used for the development of diabetes in the experimental rats

Summary

Introduction

Diabetes mellitus (DM) is a disease in which homeostasis of carbohydrate, protein and lipid metabolism is improperly regulated by hormone insulin resulting in elevation of fasting and postprandial blood glucose levels. Group IV: Diabetic control + C. asiatica aqueous extract (2 ml once a day orally for 10 days). Group V: Normal rats receiving C. asiatica aqueous extract (2 ml once a day orally for 10 days).

Results

Conclusion