Abstract
One important therapeutic approach for the treatment of Type 2 Diabetes Mellitus is by decreasing the postprandial increase of glucose. This is possible by inhibiting carbohydrate hydrolyzing enzymes like alpha-amylase. In the present study, the percentage inhibitory effects of flavonoids and crude extracts isolated from stem bark of Mangifera indica Linn. collected from Jaipur and Bharatpur districts of Rajasthan were studied with salivary alpha amylase and starch as substrate using chromogenic DNSA method & starch iodine method. All experiments were performed in 3 different sets each in triplicates. The data are expressed as mean ± SEM (standard error of the mean). The results clearly indicated that highest inhibition (57.08% and 58.24%) was obtained at the concentration of 1.5 mg/ml of flavonoids extracted from plants in both Jaipur and Bharatpur districts respectively, with an IC50 value of 0.009 mg/ml and 0.021 mg/ml respectively. All crude extracts have shown less than 50% inhibition of alpha amylase activity. Thus the results are clearly indicating that the flavonoids might be more effective than other crude extracts in lowering postprandial hyperglycemia.
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