Abstract
Otostegia persica has been used in the Iranian traditional medicine for the treatment of diabetes, because of it, the antidiabetic effect of aqueous extract of Otostegia persica root was investigated in alloxan-induced diabetic rats. In the present study oral administration of the aqueous extract of Otostegia persica root (200, 300 and 400 mg/kg body wt.) were investigated for 28 days. The level of serum glucose, total cholesterol, triglyceride (TG), high density ipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), aspartate amino transferase (AST) and alanine amino transferase (ALT) were evaluated in diabet rats. The aqueous extract of Otostegia persica roots in all doses significantly decreased serum glucose and HDL levels when compared with diabetic control rats. In the dose of 300 mg/kg body wt, ALT and TG levels were significantly decreased. A comparison was made between the action of Otostegia persica root extract and metformin (50 mg/kg body wt.), the known antidiabetic drug. The antidiabetic effect of the extract was the same as the metformin. It is concluded that this part of plant might be considered as excellent candidate for future study on diabetes mellitus.
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