Antidiabetic effects of <i>Catharanthus roseus</i>, <i>Azadirachta indica</i>, <i>Allium sativum</i> and glimepride in experimentally diabetic induced rat

Abstract

Catharanthus roseus (Nyantara), Azadirachta indica (Neem), Allium sativum (Garlic) are medicinal plants, used in Ayurveda for treating various diseases, one of which is diabetes mellitus. In the present study of 12 months period from January to December 2007, aqueous extract of this plants were prepared and blood glucose lowering effect and improvement of body weight gain in Streptozotocin (50 mg/kg bwt i.p.) induced diabetic rats were measured and compared with that of a patent drug glimepride in the Department of Pharmacology, Bangladesh Agricultural University, Mymensingh. Rats were administered Catharanthus roseus, Azadirachta indica, Allium sativum extracts at the dose rate of 1g/kg, 500 mg/kg and 1g/kg bwt orally for 14 days, respectively. Blood glucose level and body weight was measured by Glucotrend kit and Electronic balance and that compared with a patent drug Glimepride at a dose rate of 100 mg/kg bwt. The data were compared statistically by using student's unpaired t-test. The herbal preparations of these plants significantly increased body weight gain and decreased blood glucose as compared with the patent drug. The present study clearly indicated the significant antidiabetic activity of Catharanthus Roseus, Azadirachta indica and Allium sativum and supports the traditional usage of the herbal preparations by Ayurvedic physicians for the therapy of diabetics. Key words: Catharanthus roseus, Azadirachta indica, Allium sativum, Glimepride, Streptozotocin, diabetic rat DOI = 10.3329/bjvm.v5i1.1324 Bangl. J. Vet. Med. (2007). 5 (1 & 2): 99-102