Abstract
This study investigated the effect of Corni Fructus (Cornus officinalis Sieb, et Zucc.) extract on blood glucose and insulin resistance in db/db mice. Seven weeks old male mice were divided into normal control group (NC), diabetic control group (DC) and Corni Fructus treated diabetic group (DCF). Over an 8-week experimental period, Corni Fructus extract was administered orally at 500 mg/kg BW/day. Corni Fructus inhibited increase in blood glucose level during the OGTT (oral glucose tolerance test). At 8 weeks after beginning of the experiment, blood glucose level in the DCF group was significantly lower (p<0.01) than the DC group. Final fasting serum glucose and triglyceride in the DCF group were significantly lower (p<0.05) than the DC group by 32% and 41% respectively. Serum insulin did not differ among the NC, DC and DCF groups. The mRNA expression of adiponectin, GLUT 4 and PPAR-γ in adipose tissue in the DC group were significantly lower than the NC group and they were higher in the DCF group than the DC group by 76%, 130% (p<0.05) and 43%, respectively. In conclusion, these results indicated that Corni Fructus would have antidiabetic effects via improving insulin resistance in favor of higher glucose utilization and reducing blood glucose level in db/db mice.
Highlights
Diabetes mellitus is the complex metabolic disease caused by an absolute or relative lack of insulin and resulting in deleterious effects on both the macrovascular and microvascular systems (Zimmet et al, 2001)
Body weight gain in diabetic control group (DC) and db mice fed Corni Fructus extract (DCF) groups were higher than the normal control group (NC) group and it was higher in the DCF group than the DC group by 33%
Food efficiency ratio in the DC group was lower than the NC group and it was higher in the DCF group than the DC group by 51% (Table 1)
Summary
Diabetes mellitus is the complex metabolic disease caused by an absolute or relative lack of insulin and resulting in deleterious effects on both the macrovascular and microvascular systems (Zimmet et al, 2001). Insulin deficiency due to autoimmunity mediated depletion of pancreatic ~-cells is considered as the etiology of type I diabetes mellitus (insulin dependant diabetes mellitus; IDDM). Both impaired insulin secretion and insulin resistance are two main characteristics for type 11 diabetes mellitus (non-insulin dependant diabetes mellitus; NIDDM) (Pickup and Williams, 2003). Diabetes mellitus is a chronic disease that cannot be completely cured and may develop various complications if not properly treated. It has been reported that Corni Fructus has beneficial effect on advanced glycation end product-mediated renal injury in STZ-treated diabetic rats (Yamabe et al, 2007). Beneficial effects of Corni Fructus on the hyperglycemia and insulin resistance in db/db mice have not yet to be explored
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