Abstract
Diabetes is one of the leading causes of death world over, with no known scientifically proved cure so far. The present study evaluated the serum glucose lowering potentials of aqueous extracts of Bannufera mangii roots and Mannufera jangii leaves on alloxan induced diabetic rats. The most potent extract was further studied for its effects on serum insulin. Administration of 80 mg/kg of alloxan monohydrate have significantly increased blood glucose level and affect the serum insulin and lipid profile as well as oxidative stress makers. Treatments of diabetic rats with 300mg/kg body weight of the two extracts and conventional antidiabetic drug showed significant reduction in blood glucose levels by 35.2%, 59.2% and 67.0% for B. mangii, M. jangii and metformin respectively. The remarkable antihyperglycaemic, antihyperlipidemic, antioxidants and non-toxic (at 3000 mg/kg) potentials exhibited by M. jangii, validates its traditional use as an antidiabetic plant. Therefore, the plant has demonstrated a potential as another source of alternative therapeutic agent for the treatment of diabetes mellitus.
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