Abstract
Diabetes mellitus is a metabolic disorder and characterized by high blood sugar (hyperglycemia). The symptoms of diabetes mellitus include excessive urine production, increased fluid intake and increased appetite. In the present study, we examined antidiabetic potential of methanol extracts of various brown algae collected near Korean ocean. Among them, we focused our research on Ecklonia cava (E. cava), which shows a relatively high level of polyphenol contents in its extract. We found that E. cava methanol extract (EME) showed a strong radical scavenging activity from DPPH assay. From cell‐based glucose uptake assay, we observed that EME enhanced glucose uptake in C2C12 cells in the presence or absence of insulin comparing with untreated respective controls. In streptozotocin‐induced type 1 diabetes mellitus SD rats, the high blood glucose level was significantly decreased to normal range by the treatment with EME (300 mg/kg). Furthermore, we could observe significant decreases in food intake and water intake of diabetic rats treated with EME. In conclusion, the present data suggest that E. cava methanol extract has a therapeutic potential in diabetes. <This research was supported by grants from MarineBio 21 Project, the Ministry of Maritime Affairs and Fisheries, Republic of Korea.>
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