Abstract
Antihyperglycaemic effect of aqueous root extract of male Carica papaya L. (Family: Caricaceae) was investigated in alloxan-induced albino rats. 500 mg/kg body weight extract was administered by gavage orally twice daily for 7 days. Consequent upon induction of diabetes, the resulting raised levels of blood glucose, cholesterol, bilirubin, alanine aminotransferase (ALT) and alkaline phosphatase (AP) were significantly (p<0.05) reduced after one week of administering the extract. In contrast, the significant decrease in total plasma protein of rats injected with alloxan were significantly (p<0.05) increased following administration of extract compared to diabetic control rats. The results indicate the aqueous extract of male Carica papaya root ameliorated hyperglycaemia and hypercholesterolaemia lending credence to its folkloric use as treatment for diabetes mellitus. Furthermore, the extract ameliorated hepatic tissue injuries in the diabetic rats. Keywords: Carica papaya L., antihyperglycaemic, diabetic rats, aqueous, root, extract DOI: 10.7176/JNSR/10-6-01 Publication date: March 31 st 2020
Highlights
Diabetes mellitus is a chronic disorder of carbohydrate, fat and protein metabolism
Type 1 diabetes formerly called InsulinDependent Diabetes Mellitus (IDDM) or juvenile onset diabetes accounts for 5% to 10% of all cases of diabetes
This study aims at investigating the antidiabetic claims of the aqueous extract of male C. papaya root by studying indices of diabetes mellitus such as glucose, cholesterol as well as total protein, bilirubin and liver marker enzymes using albino rats
Summary
Diabetes mellitus is a chronic disorder of carbohydrate, fat and protein metabolism. A relative or absolute deficiency in insulin secretory response, which translates into carbohydrate (glucose) use, is a characteristic feature of diabetes (James et al, 2003). One type of classification was proposed in 1997 by the American Diabetes Association based on etiology. These are diabetes types 1 and 2. Type 1 diabetes formerly called InsulinDependent Diabetes Mellitus (IDDM) or juvenile onset diabetes accounts for 5% to 10% of all cases of diabetes. In type 2 diabetes, up to 80% of patients are involved. It was previously called Non-Insulin-Dependent Diabetes mellitus (NIDDM) or adult onset diabetes (Frier & Fisher, 2002). Long term complications include retinal damage, nerve damage, microvascular disease, cardiovascular disease, liver damage, renal failure etc. if the disease is not adequately controlled
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