Abstract
Heritiera fomes (Sundari) have been accepted as a supplement for the treatment of pre and post diabetes. The present study investigated the effects of ethanol extract of H. fomes (EEHF) on insulin release from clonal pancreatic β-cells and mouse islets and protein glycation, starch digestion, glucose diffusion, DPP-IV enzyme activity in vitro and glucose homeostasis in type 2 diabetic rats. EEHF, significantly stimulated insulin release in concentration-dependent manner from BRIN-BD11 cells and isolated mouse islets with stimulatory effects equivalent in magnitude to 1µM GLP-1. Insulinotropic effects of H. fomes (200µg/ml) on BRIN-BD11 cells were partly inhibited by verapamil, diazoxide and calcium free conditions showing importance of ion channels and Ca2+in mechanism of action. Secretion was further potentiated by activation of augmentation pathways revealed using IBMX, tolbutamide and
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