Abstract

Heritiera fomes (Sundari) have been accepted as a supplement for the treatment of pre and post diabetes. The present study investigated the effects of ethanol extract of H. fomes (EEHF) on insulin release from clonal pancreatic β-cells and mouse islets and protein glycation, starch digestion, glucose diffusion, DPP-IV enzyme activity in vitro and glucose homeostasis in type 2 diabetic rats. EEHF, significantly stimulated insulin release in concentration-dependent manner from BRIN-BD11 cells and isolated mouse islets with stimulatory effects equivalent in magnitude to 1µM GLP-1. Insulinotropic effects of H. fomes (200µg/ml) on BRIN-BD11 cells were partly inhibited by verapamil, diazoxide and calcium free conditions showing importance of ion channels and Ca2+in mechanism of action. Secretion was further potentiated by activation of augmentation pathways revealed using IBMX, tolbutamide and

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.