Abstract
This study was undertaken to investigate the antidiabetic and antioxidant activities of crude extracts and pure compounds from the aerial parts of Calamintha officinalis Moench. (Lamiaceae). The aqueous extract showed the promising antidiabetic and antioxidant activities. Based on these findings, the aqueous extract was fractionated on a silica gel column chromatography in a bioassay-guided fractionation affording two known hydroxycinnamic acids showing potent activity (1) rosamarinic acid and (2) caffeic acid. Both rosamarinic acid and caffeic acid exhibited significant activity, even more than the positive control, glibenclamide. The results indicated that Calamintha officinalis aqueous extract and the isolated compounds are potential natural agents for the control of diabetes.
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