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Abstract
Introduction: Sida acuta is known as common wireweed, and has a pantropical distribution. Antioxidants fight against free radicals and prevent a variety of diseases. Anti Inflammatory reaction is the ability of a substance to reduce swelling or inflammation. Antidiabetic substances are defined as agents which help in maintaining the level of glucose in the blood.
 Aim: Present study was aimed at assessing the in vitro antidiabetic and antiinflammatory potentials of Sida acuta leaf ethanolic extract. 
 Methods: Sida acuta was purchased and its ethanolic extract was prepared. Protein denaturation inhibition, DPPH radical scavenging, alpha amylase and alpha glucosidase inhibitory assays were carried out in order to check in vitro antiinflammatory, antioxidant and antidiabetic activity spectrophotometrically.. The data were analysed using one-way analysis of variance (ONE-WAY ANOVA) to see the statistical significant among the different concentrations of extract. P<0.05 levels were considered as statistical significance.
 Results: The extract of Sida acuta was compared with aspirin and an antiinflammatory reaction was analysed. Statistically significant at the levels of p < 0.05.The extract proved to contain antiinflammatory and antioxidant reactions. Alpha amylase and alpha glucosidase activity was analysed by comparing the extract with metformin.
 Conclusion: Sida acuta can be used for the management and treatment of various diseases and disorders. It can be used for the treatment of diabetes and cancer.
Highlights
Sida acuta is known as common wireweed, and has a pantropical distribution
Sida acuta antiinflammatory property was analysed compared with aspirin and antidiabetic property was assessed using alpha amylase and alpha glucosidase tests compared with metformin
By comparing the article of Marimuthu, it was seen that crude extract of Sida acuta exhibits larvicidal and repellent activities, having the ability to control Culex quinquefasciatus, aedes aegypti and anopleles mosquitoes
Summary
Sida acuta is known as common wireweed, and has a pantropical distribution. DPPH radical scavenging, alpha amylase and alpha glucosidase inhibitory assays were carried out in order to check in vitro antiinflammatory, antioxidant and antidiabetic activity spectrophotometrically. Results: The extract of Sida acuta was compared with aspirin and an antiinflammatory reaction was analysed. Significant at the levels of p < 0.05.The extract proved to contain antiinflammatory and antioxidant reactions. Conclusion: Sida acuta can be used for the management and treatment of various diseases and disorders. Sida acuta, is known as the common wireweed, is a species of flowering plant in the mallow family, Malvaceae. It originated in Central America, but has a pantropical distribution. Since sida Acura has a narrow spectrum of activity it is useful in treating infections of Gram positive bacteria
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