Abstract
Dracaena Cinnabari balfis a species plant in Abalfurn 1984e de la p pharmaciegavaceae family. It is a tree endemic to the Island of Socotra,Yemen. It was used as a dye and medicine in Socotra and the Mediterranean basin. Some researches demonstrated both hypoglycemic and hypolipidemic of its resin of Dracaena Cochinchinensis, a traditional Chinese tree. Accordingly, this study aimed to evaluate the antidiabetic potential of the ethanolic extract of dracanea cinnabari balfresin (DCBR), endemic in Socotra Island, in Alloxan induced diabetes, and evaluation of possible antihyperlipidemic activity of the same extract in high-cholesterol diet-induced hyperlipidemia in male albino rats. Experimental diabetes was induced in rats with intraperitoneal injection a single dose of Alloxan (150 mg/kg). Hyperlipidemia was induced in rats by administration of 1% cholesterol in diet and 0.5 % Hydrogen Peroxide in drinking water for 14 days. Fasting blood glucose levels were measured at 1st day, 7th day and 14th day. Pancreas histopathology was done at the end. Estimation of serum lipid profile and liver histopathology was done at the end of 14 day. The results were expressed as mean ± SD and differences among the groups of animals were compared using one-way ANOVA. Administration of ethanolic extract of resin of two doses (100mg and 300mg\kg) in alloxan induce diabetic rats resulted in a significant decrease in FBG levels with a recovery in destruction of pancreas cell compared with untreated group .Also the same doses of extract showed significant decrease in triglycerides, total cholesterol, low density lipoprotein, very low density lipoprotein and alkaline phospatase in comparing with untreated groups. From the results of present study we can conclude the ethanolic extract of Dracaena Cinnabari Balf. have a hypoglycemic and hypolipidemic activity in experimental animals , these activity are time and dose dependent.
Highlights
Diabetes mellitus is a group of metabolic disorders characterized by elevated levels of glucose in blood due to insufficient production of insulin or because cells do not respond to insulin produced[1]
We got the same result with group 5 which was treated with 2.5 mg/Kg Glibenclamide, whereas group 4 which was treated with 300 mg/Kg Dracanea cinnabari balf resin (DCBR) extract, showed a significant increase in the pancreas weight in comparison to group 2
Biochemical investigation (FBG) The groups 2, 3, 4 and 5 which were injected with 150mg/Kg alloxan showed a significant increase in the FBG values more than 200mg/dl (p-value ≤ 0.05) in comparison to group 1
Summary
Diabetes mellitus is a group of metabolic disorders characterized by elevated levels of glucose in blood (hyperglycemia) due to insufficient production of insulin or because cells do not respond to insulin produced[1]. Management strategies of diabetes include life style intervention through diet modification and exercise and the use of oral hypoglycemic therapy and insulin treatment[4]. World Health Organization (WHO) approved the use of plant drugs for different diseases[8] including diabetes mellitus[9] and hyperlipidemia[10]. One of these plants is Dracanea cinnabari, known as Dam Al Akhawain. No previous studies about in vivo antidiabetic and antihyperlipedimec activity of Dracaena cinnabari balf resin that is a species plant endemic to the Island of Socotra, Yemen. The current study was done to prove the antidiabetic and antihyperlipedimec activity of Dracaena cinnabari balf resin ethanolic extract in experimental animals
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