Abstract
The use of nanoparticles in medicine is an attractive proposition. In the present study, zinc oxide and silver nanoparticles were evaluated for their antidiabetic activity. Fifty male albino rats with weight 120 ± 20 and age 6 months were used. Animals were grouped as follows: control; did not receive any type of treatment, diabetic; received a single intraperitoneal dose of streptozotocin (100 mg/kg), diabetic + zinc oxide nanoparticles (ZnONPs), received single daily oral dose of 10 mg/kg ZnONPs in suspension, diabetic + silver nanoparticles (SNPs); received a single daily oral dose of SNP of 10 mg/kg in suspension and diabetic + insulin; received a single subcutaneous dose of 0.6 units/50 g body weight. Zinc oxide and silver nanoparticles induce a significant reduced blood glucose, higher serum insulin, higher glucokinase activity higher expression level of insulin, insulin receptor, GLUT-2 and glucokinase genes in diabetic rats treated with zinc oxide, silver nanoparticles and insulin. In conclusion, zinc oxide and sliver nanoparticles act as potent antidiabetic agents.
Highlights
IntroductionA large number of people suffer from diabetes all over the world [1]
Diabetes mellitus is a metabolic disorder that characterized by high blood glucose
In the present study we evaluated the possible therapeutic effect of zinc oxide and silver nanoparticles on streptozotocin-induced diabetic rats as well as their compared effect to insulin treatment
Summary
A large number of people suffer from diabetes all over the world [1] These patients would require the development of several medications with multiple modes of actions. An essential metal, is an activator for more than three hundred enzymes in the body [6], and plays a key role in different metabolic pathways including glucose metabolism. Silver is an important metal in a huge number of metabolic processes; there is no data about the effective power of silver or silver nanoparticles (SNP) on the glucose status. This encourages us to study the effect of SNP in comparison with ZnONPs
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