ANTIDIABETIC ACTIVITY OF SWARNA MAKSHIKA BHASMA, SHUDDHA SHILAJATU AND THEIR COMBINATION IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RATS

Abstract

Swarna makshika bhasma and Shilajatu are mentioned by Acharya Sushruta in Madhumeha Chikitsa. These two Rasayanas play a role in glucose and insulin metabolism. The present study was undertaken to assess the anti-diabetic activity in Wistar strain albino rats, thirty-six in number divided into six groups. Streptozotocin was given to induce diabetes. Glibenclamide was used as a standard control drug. Doses of all drugs in each group were according to an accepted standard. Mild diabetic rats (blood sugar > 200 mg/dL) were given medication after their body weight and blood glucose levels were determined. The treatment was maintained on days 7, 14, 21, and 28, and biochemical parameters were calculated. From the fourth day of Streptozotocin induction of diabetes, Makshika bhasma, Shuddha shilajatu and their combination, Glibenclamide, were given once daily. After administration, the effects of Swarna makshika bhasma, Shuddha shilajatu, and Combination of Makshika bhasma and Shuddha shilajatu on bodyweight were statistically non-significant. However, there was a distinction between the before and after-effects. The most remarkable changes in blood glucose levels were reported for Makshika bhasma, Shuddha shilajatu, and Makshika bhasma with Shuddha shilajatu. To conclude, the Combination of Shilajatu and Makshika bhasma is the most efficient and remarkably therapy alternative in Madhumeha. Their multifaceted impact makes them a viable method in the long-term control of diabetes.