Abstract
Objective: The main purpose of the present study was to analyze the antidiabetic activity of methanolic extract of the leaf of Kalanchoe pinnata in alloxan-induced diabetic rats.
 Methods: Diabetes mellitus (DM) is a chronic metabolic and endocrine disease regarded as a serious global public health problem. Albino Wistar rats were divided into four groups. Group I (normal) received drinking water throughout the course till 20 days. Groups II-IV received alloxan (120 mg/kg b.w) i.p on the 1st day of the study period. Group III animals received glibenclamide (10 mg/kg p.o) and Group IV received K. pinnata (200 mg/kg b.w p.o) for 20 days. The body weight, blood glucose level, serum urea, blood urea nitrogen (BUN), creatinine, cholesterol, total protein (TP), uric acid, and tissue (liver) antioxidant parameters: Malondialdehyde (MDA) and glutathione (GSH) were measured.
 Results: K. pinnata treated rats showed the percentage increase in the body weight, decrease in the blood sugar level, creatinine, TP level, urea, uric acid, and BUN, MDA, and GSH when compared to alloxan-induced diabetic mellitus control rats. Thus, K. pinnata could be possibly employed to treat DM.
 Conclusion: This preliminary analysis tested the most promising profile. It seems that methanolic extract of the leaf of K. pinnata improved general, blood serum, and liver antidiabetic agent. However, further studies confirming its potential is certainly warranted.
Highlights
Fast-growing socioeconomic development in the past 10 years has revealed a rise in the lifestyle disorders among which diabetes mellitus (DM) is growing rapidly and has turned out to be like an epidemic in many parts of the world
Groups III and IV DM rats treated with glibenclamide and MLEKP showed an increase in the body weight level when compared to Group II DM control rats
Groups III and IV DM rats treated with glibenclamide and MLEKP have shown significant decrease in the blood glucose levels when compared to Group II DM control rats
Summary
Fast-growing socioeconomic development in the past 10 years has revealed a rise in the lifestyle disorders among which diabetes mellitus (DM) is growing rapidly and has turned out to be like an epidemic in many parts of the world. Statistical projection of India suggests that it is speculated to have the highest number of diabetics in the world since the number of diabetics will rise from 15 million in 1995 to 57 million in 2025 Reasons for this rise include an increase in sedentary lifestyle, consumption of energy-rich diet, obesity, and a higher life span [2]. Kalanchoe pinnata is a succulent perennial plant that grows 3–5 feet tall It commonly known as “air plant,” it has tall hollow stems, fleshy dark green leaves that are distinctively scalloped and trimmed in red, and bell-like pendulous flowers. Autoxidation of dialuric acid generates superoxide radicals, hydrogen peroxide, and, in a final iron-catalyzed reaction step, hydroxyl radicals These hydroxyl radicals are responsible for the death of the beta-cells [4]. The methanolic extract of the leaves of K. pinnata was used to evaluate its antidiabetic efficacy in alloxaninduced diabetic rats
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