Abstract
So far, diabetes mellitus has become a health threat to society all over the world. Especially, people with diabetes have always coped with complications related to this disease and unexpected side effects of synthetic drugs. Thus, there has been a current trend for researchers to find out new natural ingredients which were safer and still effective in the treatment of diabetes. Gomphogyne bonii Gagnep. extract (G. bonii extract) was an herbal-derived product of the Pharmacy Department, Vietnam University of Traditional Medicine. This study was designed to assess the antidiabetic effect of G. bonii extract on a high-fat diet (HFD) and alloxan-induced diabetes in mice. Mice were first fed a high-fat diet for 8 weeks and then given an intraperitoneal injection of alloxan (ALX) at the dose of 180 mg/kg b.w. After the diabetic mice model was successfully established, mice were administered orally with G. bonii extract at two doses of 4 mL/kg b.w/day and 12 mL/kg b.w/day for 2 weeks. The results revealed that G. bonii extract at both doses ameliorated the effects of ALX on the concentration of glucose, total cholesterol (TC), triglyceride (TG), and low-density lipoprotein-cholesterol (LDL-C) and microhistological images of livers. Besides, the antidiabetic effect of G. bonii extract at the dose of 12 mL/kg b.w/day was better than that at the dose of 4 mL/kg b.w/day. This suggested that G. bonii extract could be a potential agent for treating diabetes mellitus in clinical practice.
Highlights
Diabetes is a chronic, metabolic disorder as a consequence of elevated levels of blood glucose
At all time points, there was a substantial rise in the weight of mice at the group fed with high-fat diet (HFD) as compared with the group fed with normal-fat diet (NFD) (p < 0.001)
After 8 weeks of HFD and after 72 hours of ALX injection, the blood glucose levels at group II posed a significant development as compared with group I (p < 0.01 and p < 0.001, respectively)
Summary
Metabolic disorder as a consequence of elevated levels of blood glucose. According to the IDF Diabetes Atlas (2019), the number of people with diabetes aged 20–79 years increased by 312 million (4.7% of the global population) from 2000 to 2019. Diabetes has become one of the top 10 causes of death, and the number of deaths from diabetes went up by 70% from 2000 to 2019 [3]. Due to the complications of diabetes, diabetic patients have become burdens to the families and society, leading to the health system overload. Oral antihyperglycemic drugs derived from synthetic materials were mainly used to treat diabetes, for example, sulfonylureas and biguanides. Ese synthetic drugs, caused lots of undesirable effects such as hypoglycaemia, hepatobiliary disorders, and gastrointestinal disturbances [4] Oral antihyperglycemic drugs derived from synthetic materials were mainly used to treat diabetes, for example, sulfonylureas and biguanides. ese synthetic drugs, caused lots of undesirable effects such as hypoglycaemia, hepatobiliary disorders, and gastrointestinal disturbances [4]
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