Abstract
Antidiabetic Activity of Aqueous Seed Extract of Securigera securidaca in Streptozotocin Induced Diabetic Rats
Highlights
Diabetes mellitus (DM) is a metabolic and multifactorial disorder characterized by a chronic increase in blood sugar, or hyperglycemia, due to insulin insufficiency, its malfunction or both [1,2,3]
Based on the results, Securigera securidaca seed extract had a significant effect in reducing the blood sugar of diabetic rats with no significant changes in lipid profiles
The results revealed a significant difference in weight among the different groups and the control group after 7 days (p ≤ 0.0001); the weight of the rats in the different groups was lower than that of rats in the control group
Summary
Diabetes mellitus (DM) is a metabolic and multifactorial disorder characterized by a chronic increase in blood sugar, or hyperglycemia, due to insulin insufficiency, its malfunction or both [1,2,3]. The treatment of DM is based on insulin and oral anti-diabetic drugs. Even with the prolonged use of insulin, various problems arise, such as insulin resistance, anorexia, brain atrophy, and fatty liver [6]. The long-term use of oral hypoglycemic agents is associated with unwanted side effects, including hypoglycemia and weight gain [7]. Research must be done on a newer anti-diabetic agent that has better therapeutic effects and fewer side effects. Securigera securidaca is a medicinal plant used in Persian folk medicine to decrease blood sugar. The current study investigated the hypoglycemic activity of the aqueous seed extract of Securigera securidaca
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