Abstract
BackgroundMoringa stenopetala has been used in traditional health systems to treat diabetes mellitus. The aim of this study was to investigate the antidiabetic activity of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin (STZ) induced diabetic rats.MethodsThe aqueous ethanol extract and n-butanol fraction of Moringa stenopetala leaves hydroalcoholic (500 mg/kg body weight) and metformin (150 mg/kg body weight) were administered to diabetic rats. Blood glucose, lipid profiles, liver and kidney function were examined after 14 days of experiment. Histopathological profile of the pancreas was also observed in diabetic rats at the end of study. An oral sucrose challenge test was also carried out to assess the post prandial effect of the extract.ResultsOral administration of the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves (500 mg/kg body weight) and metformin (150 mg/kg) significantly reduced blood glucose level (P < 0.05), improved serum lipid profiles, liver enzymes and kidney functions in diabetic rats after 14 days. The extracts also improved damage of islet of Langerhan’s in diabetic rats. The plant material reduced the post-prandial glucose level (P < 0.001) at the dose of 750 mg/kg.ConclusionThese findings revealed that both the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves possess antihyperglycemic and antihyperlipidemic properties, and alleviate STZ-induced pancreatic damage in diabetic rats. The beneficial effects of plant material in inhibition of diabetes-induced complications are being investigated.
Highlights
Moringa stenopetala has been used in traditional health systems to treat diabetes mellitus
Effect of Moringa stenopetala leaf extract on postprandial glycemia in non-diabetic mice A single oral administration of Moringa stenopetala extract was given to non-diabetic rats to confirm its antihyperglycemic activity by oral sucrose tolerance test
The groups treated with the aqueous ethanol extract and nbutanol fraction of Moringa stenopetala leaves showed significant reduction of blood glucose level on day 7 and 14 after administration
Summary
Moringa stenopetala has been used in traditional health systems to treat diabetes mellitus. The aim of this study was to investigate the antidiabetic activity of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin (STZ) induced diabetic rats. The crude aqueous/ethanol extract and fractions of the leaves of Moringa stenopetala have been reported to have both hypoglycemic and antihyperglycemic effects [10, 11]. Chronic administration of the nbutanol fraction of ethanol extract of Moringa stenopetala leaves in alloxan-induced diabetic mice showed antihyperglycemic and antihyperlipedimic effects with wide margins of safety, indicating its potential for long term management of diabetes and dysilipidemia through enzyme inhibition mechanisms [12,13,14]. The aim of the present study was to investigate the pancreatoprotective effect of the aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves on streptozotocin (STZ)-induced diabetic rats on blood glucose, serum lipid levels, hepatic enzymes and kidney function
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