Abstract
Different ethnobotanical studies refer that the main use of Anoda cristata (Malvaceae) is as food, however it is also employed to treat stomach inflammation, fever, cough, wounds and diabetes. In this work we describe the antidiabetic action of an infusion of A. cristata and its major compounds [acacetin (1) and diosmetin (2)] using different pharmacological animal models. The free-mucilage aqueous extract (100 and 316 mg/kg) reduced glucose and triglyceride blood levels and increased insulin levels in metabolic syndrome-induced rats. The aqueous extract (31.6, 100 and 316 mg/kg) provoked significant hypoglycemic and antihyperglycemic effect in diabetic NA-STZ (50; 130 mg/kg, i.p.) mice, and compounds 1 and 2 (3, 10 and 31.6 mg/kg) have also significant hypoglycemic effect. This work provides scientific evidence supporting the use of A. cristata as antidiabetic agent in folk medicine.
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