Abstract
ABSTRACT Aim: The in vitro antidermatophytic activity of methanol leaf extract of Musa sapientum (MSL) against Microsporum canis, Trichophyton tonsurans and Trichophyton rubrum was investigated. Methodology: The methanol leaf extract M. sapientum was obtained by cold extraction. The antifungal activity of the extract was assayed using agar well diffusion techniques. The time-kill antibacterial kinetics of the extract was assessed against one strain of M. canis and two strains of T. tonsurans by plate count technique. Results: The extract had minimum fungicidal concentration (MFC) and minimum inhibitory concentration (MIC) values ranging from 0.0625 mg/ml to 0.5 mg/ml. The least MIC and MFC value was 0.0625 mg/ml against M. canis while T. tonsurans showed the highest MIC and MFC value of 0.5 mg/ml. The extract had no inhibitory or fungicidal effect against T. rubrum . Time-kill kinetic study indicated that the extract exhibited bacteriostatic and bacteriocidal effects against Microsporum canis and Trichophyton tonsurans. Conclusion: The results obtained suggest that the methanol leaf extract of Musa sapientum possesses antidermatophytic properties. Original Research Article
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