Abstract
Two new benzyl derivatives were isolated from ethyl acetate fraction of wild strawberry, Fragaria vesca var. nubicola Lindl. ex Hook.f. The structures of these compounds were elucidated to be 5-(4-hydroxy-3-methoxyphenethyl)-7-methoxy-2H-chromen-3-ol (1) and 5-(4-hydroxy-3-methoxyphenethyl)-4,7-dimethoxy-2H-chromen-3-ol (2) based on spectroscopic data through IR, UV, 1H-NMR, 13C-NMR along with two dimensional (2D) techniques HMBC, HMQC, and COSY. Both compounds 1 and 2 were studied in tail suspension and forced swim tests for antidepressant like effects. A significant dose dependent antidepressant like effect was observed by causing spontaneous anti-immobility at various test doses upon intraperitoneal administration.
Highlights
Fragaria vesca var. nubicola Lindl. ex Hook.f.; commonly known as wild strawberry is synonym of Fragaria nubicola (Lindl. ex Hook.f.) Laciata
The family Rosaceae comprises of 85 genera and nearly about 3000 species widely distributed in Europe and North America while represented by 27 genera and about 160 species in Pakistan (Stewart, 1972; Mabberley, 2008)
Two new benzyl derivatives have been isolated from ethyl acetate fraction of F. vesca var. nubicola through successive column chromatography, while characterization was made through various spectroscopic techniques and comparison with literature
Summary
Fragaria vesca var. nubicola Lindl. ex Hook.f.; commonly known as wild strawberry is synonym of Fragaria nubicola (Lindl. ex Hook.f.) Laciata. Ex Hook.f.; commonly known as wild strawberry is synonym of Fragaria nubicola It is a perennial herb belonging to family Rosaceae that mostly grows along roadsides and in forests. The family Rosaceae comprises of 85 genera and nearly about 3000 species widely distributed in Europe and North America while represented by 27 genera and about 160 species in Pakistan (Stewart, 1972; Mabberley, 2008). The vegetative parts of F. vesca var. The achenes and thalamus parts of F. vesca has been reported to have high phenolic content and showed good antioxidant activity (Cheel et al, 2007). Nubicola has potential analgesic and anti-oxidant activity (Kanodia and Das, 2008; Kanodia et al, 2011). Nubicola possesses anti-convulsant activity and is effective for treatment of epilepsy (Patil et al, 2012) The ethanolic extract of F. vesca var. nubicola possesses anti-convulsant activity and is effective for treatment of epilepsy (Patil et al, 2012)
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