Abstract

Preface.- Section 1. Basic Principles: Pharmacologic Science: 1. Biochemical and Physiological Processes in Brain Function and Drug Actions. 2. General Principles of Pharmacokinetics. 3. Therapeutic Drug Monitoring of Antidepressants.- Section 2. Basic Principles: Clinical Science: 4. Biological Markers of Depression. 5. The Importance of Quality of Life and Rating Scales of Depression.- Section 3. Current Pharmacotherapy of Major Depressive Disorder: 6. Overview of Currently Available Antidepressants. 7. Tricyclic Antidepressants. 8. Monoamine Oxidase Inhibitors. 9. Selective Serotonin Reuptake Inhibitors. 10. Atypical Antidepressants. 11. Current Role of Herbal Preparations.- Section 4. Use of Antidepressants in Special Populations: 12. Children and Adolescents. 13. Women. 14. Older Adults. 15. Bipolar Mood Disorders. 16. Treatment-Refractory Depression. 17. Personality Disorders.- Section 5. Future Directions in the Treatment of Major Depressive Disorder: 18. New Hypotheses to Guide Future Antidepressant Drug Development. 19. Promising New Directions in Antidepressant Development. 20.Role of Pharmacogenetics/Pharmacogenomics in the Development of New Antidepressants.

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