Abstract

Depression can disrupt neural circuits in depression. This industry-supported study used rodents to examine how two antidepressants with grossly different actions affect a neural reward circuit involving the prefrontal cortex (PFC), nucleus accumbens, hippocampus, and amygdala. This circuit is involved in susceptibility, resistance, and antidepressant response to depressogenic circumstances. The test used here was social defeat stress (SDS), a validated animal model of depression. Identically raised inbred mice were determined …

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