Abstract
Serotonergic and opioid systems have been implicated in major depression and in the action mechanism of antidepressants. The organoselenium compound m-trifluoromethyl-diphenyl diselenide ( m–CF 3–PhSe) 2 shows antioxidant and anxiolytic activities and is a selective inhibitor of monoamine oxidase A activity. The present study was designed to investigate the antidepressant-like effect of ( m–CF 3–PhSe) 2 in female mice, employing the forced swimming test. The involvement of the serotonergic and opioid systems in the antidepressant-like effect of ( m–CF 3–PhSe) 2 was appraised. ( m–CF 3–PhSe) 2 at doses of 50 and 100 mg/kg (p.o.) exhibited antidepressant-like action in the forced swimming test. The effect of ( m–CF 3–PhSe) 2 (50 mg/kg p.o.) was prevented by pretreatment of mice with WAY100635 (0.1 mg/kg, s.c. a selective 5-HT 1A receptor antagonist), ritanserin (4 mg/kg, i.p., a non-selective 5HT 2A/2C receptor antagonist), ondansetron (1 mg/kg, i.p., a selective 5-HT 3 receptor antagonist) and naloxone (1 mg/kg, i.p., a non-selective antagonist of opioid receptors). These results suggest that ( m–CF 3–PhSe) 2 produced an antidepressant-like effect in the mouse forced swimming test and this effect seems most likely to be mediated through an interaction with serotonergic and opioid systems.
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