Abstract
The aim of this study was to investigate the antidepressant activity of hydroalcoholic extract Agaricus blazei (273 and 819 mg/kg; orally) in stressed and unstressed Swiss albino mice. Mice were immobilized to induce stress. Fluoxetine 20 mg/kg orally was given to stressed and unstressed animals and immobility time was noted by using forced swim test and tail suspension test. The concentration of plasma nitrite was also evaluated in stressed and unstressed mice. The effect of prazosin (α1-adrenoceptor antagonist), p-CPA (parachlorophenylalanine–tryptophan hydroxylase inhibitor) and 7-nitro-indazole (nNOS inhibitor) on the antidepressant activity of A. blazei was also evaluated. A. blazei and fluoxetine significantly decreased the duration of immobility time in stressed and unstressed mice, showing significant antidepressant activity. No substantial change was found in the locomotor activity. However, a significant reduction in the level of plasma nitrite was also noted in stressed mice. Hydroalcoholic extract showed prominent antidepressant activity in mice.
Highlights
Depression is a widespread disorder in almost all the communities of the world which renders the person unable to perform the routine functions of life associated with one’s professional and social life.In clinical practice, many classes of drugs are used as antidepressant drugs which include specific serotoninnorepinephrine reuptake inhibitors, tricyclic antidepressants, selective reversible inhibitors of monoamine oxidase A and selective serotonin reuptake inhibitors
The mouse subjected to immobility stress for 150 min showed a significant increase in the immobility time
The results showed that the extract possesses significant antidepressant activity
Summary
Many classes of drugs are used as antidepressant drugs which include specific serotoninnorepinephrine reuptake inhibitors, tricyclic antidepressants, selective reversible inhibitors of monoamine oxidase A and selective serotonin reuptake inhibitors Almost all these classes of drugs have numerous adverse drug reactions such as dizziness, confusion, insomnia, dry mouth, constipation, tachycardia, profuse sweating, weight changes and sexual dysfunction (Fajemiroye et al, 2016; Fava, 2003; Bet et al, 2013). This condition creates the need for the use of medicinal plants or plant-based medications for the treatment of depression. Other plants which possess antidepressant potential are Echium amoenum (Faryadian et al, 2014; Sayyah et al, 2006), C. sativus (Shafiee et al, 201; Lopresti and Drummond, 2014), Lavandula spp. (Kageyama et al, 2012; Rahmati et al, 2017), grape seed (Rabiei et al, 2017); Hamelia patens (Surana and Wagh, 2017), Panax ginseng (Dang et al, 2009; Ge et al, 2017), Albizia julibrissin (Kim et al, 2007; Liu et al, 2015), Mentha pulegium (Rabiei et al, 2016), R. rosea (Saki et al, 2014; Mao, 2014)
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