Abstract
Depression characterized by significant depression of mood and impairment of function. In whole study evaluate the antidepressant activity of ethanolic extract of Bacopa monnieri Linn, to assess the pharmacodynamic interaction of drug with standard nootropic antidepressant, determine effect of drug alone and in combination with standard anti-depressant in brain on amino acid neurotransmitter and acetylcholine esterase activity. Despair Swim test and tail suspension test study of interaction of ethanolic extract Bacopa monnieri with standard antidepressant drug extract used in FST and TST studied. Final perception was GABAmimetic Bacopa monneri decrease the immobility in forced swim test found that GABAergic activity lower in depressed state than normal brain. The control group in both FST and TST. GABA level found decrease than basal values. From experimental evidence it may conclude that ethanolic extract of Bacopa monnieri Linn possesses significant antidepressant activity.
Highlights
The primary clinical manifestations of major depression are significant depression of mood and impairment of function
Depression characterized by significant depression of mood and impairment of function .In whole study evaluate the antidepressant activity of ethanolic extract of Bacopa monnieri Linn, to assess the pharmacodynamic interaction of drug with standard nootropic antidepressant, determine effect of drug alone and in combination with standard antidepressant in brain on amino acid neurotransmitter and acetylcholine esterase activity
Despair Swim test and tail suspension test study of interaction of ethanolic extract Bacopa monnieri with standard antidepressant drug extract used in forced swim test (FST) and TST studied
Summary
The primary clinical manifestations of major depression are significant depression of mood and impairment of function. These include insomnia or hypersomnia; altered eating patterns, with anorexia and weight loss or sometimes overeating; decreased energy and libido; and disruption of the normal circadian and ultradian rhythms of activity, body temperature, and many endocrine functions. As many as 10% to 15% of individuals with severe clinical depression, and up to 25% of those with bipolar disorder, display suicidal behaviour at some time Depressed patients usually respond to antidepressant drugs, or, in severe or treatment-resistant cases, to electroconvulsive therapy (ECT). The etiology of depressive disorders is too complex to be totally explained by a single social, developmental or biologic theory, several factors appear to work together to cause or precipitate depressive disorders [1,2,3,4,5]
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