Abstract
The effect of tricyclic antidepressants on 3H-dopamine uptake into synaptosomes obtained from rat striatum and mesolimbin cortical areas was examined. Chlorimipramine was found to be the most potent uptake inhibitor (IC 50 of 3.2–3.8 × 10 −6 M) in both brain regions. Desmethylimipramine, protiptyline and iprindole were approximately one-half as potent (IC 50 of 5.9–8.5 × 10 −6 M) in both brain areas. Kinetic constant obtained from Lineaveaver-Burk plots in both areas revealed no alteration in Km for transport and a decrease in V max thus indicating a non-competitive inhibition. The effect of chlorimipramine on the release of 3H-dopamine from striatal synaptosomes aptosomes required a concentration 10 −5 M for 50% release in 5 min. It is suggestetd that dopamine uptake inhibition may play some role in the action of tricyclic drugs, e.g., activation of schizophrenic psychopathology but that this action can not solely responsible for their antidepressant properties.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
