Antidepressant Consumption In Uruguay: Following World Trends

V Domínguez,E Pagano,L Barboza,N Speranza,G Tamosiunas

doi:10.1016/j.clinthera.2017.05.069

V Domínguez, E Pagano + Show 3 more

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https://doi.org/10.1016/j.clinthera.2017.05.069

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Abstract

Depression is a common mental disorder affecting more than 350 million people worldwide and also an increased prevalence of 11% was reported in Uruguay between 1998 and 2008. As a result, the consumption of neuropsychiatric drugs including antidepressant agents (ADs) is increasing worldwide. No data on the overall Uruguayan patterns of ADs consumption is available. To quantify and evaluate the consumption of ADs in a Uruguay between 2010 and 2014. Unit of measurement was the defined daily dose (DDD) per 1000 inhabitants per day (DHD). DHD of Selective- serotonin reuptake inhibitors (SSRIs), Serotonin-norepinephrine reuptake inhibitors (SNRLs), and tricyclic antidepressants (TCAs) were compared. Results were described as absolute values and percentage of changes. Our analysed sample represents a 71% of the Uruguayan population. Global DHD for 2010-2014 were 25.61, 28.25, 28.56, 28.95 and 31.72 (mean 28.67) DDD/1000 inhabitants/day respectively. Therefore, dispensing of antidepressant prescriptions through National Health Care System hospital’s pharmacies in Uruguay increased from an estimated 25.61 DDDs/1000 population per day in 2010 to 31.72 DDDs/1000 population/day in 2014 (19.26%). SSRIs were the most consumed antidepressants (mean 25.49) whereas other antidepressants including agomelatine, mirtrazapine and bupropion had the lowest consumption during the analyzed period (mean 0.40). Duloxetine and escitalopram showed the higher consumption increase, while the use of maprotiline and clomipramine experienced the greater decrease from 2010 to 2014. During 2013, consumption of ADs in Uruguay was higher than in Chile (13 DHD) and Korea (20 DHD) but lower than consumption in Italy (43 DHD), Spain (65 DHD), Denmark (80 DHD) and Australia (95 DHD). Uruguay showed low antidepressant consumption compared with those reported by other countries. These are the first available ADs consumption data in our country and will be useful to perform future comparisons.

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