Abstract
To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats. Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Data were analyzed by one-way ANOVA and Kruskall-Wallis. Rats given injections of duloxetine displayed fewer stops than the amitriptyline and control group (p< 0.05). The control group and Amitriptyline showed no difference (p=0.8). Duloxetine reduced depressive behaviors in the Forced Swimming Test been more effective than amitriptyline.
Highlights
The distinction between the normal depression feeling and the pathology that requires medical intervention is extremely hard to those not specialized in mental health[1]
The Diagnostic and Statistical Manual of Mental Disorders[1] describes the emotional symptoms of depression as sadness, lack of interest, guiltiness, and suicidal thoughts. This definition emphasizes the presence of emotional symptoms, physical symptoms are recognized as a key component of the depressive syndrome
We used the Forced Swimming Test (FST) to compare the effects of duloxetine and amitriptyline on antidepressive behaviors, including immobility
Summary
The distinction between the normal depression feeling and the pathology that requires medical intervention is extremely hard to those not specialized in mental health[1]. The Diagnostic and Statistical Manual of Mental Disorders[1] describes the emotional symptoms of depression as sadness, lack of interest, guiltiness, and suicidal thoughts. This definition emphasizes the presence of emotional symptoms, physical symptoms are recognized as a key component of the depressive syndrome. These physical symptoms include a lack of energy, sleep disorders, pain, headaches, changes in appetite, gastrointestinal disorders, and changes in psychomotor function. Antidepressant drugs that potently inhibit 5-HT/NE reuptake, such as duloxetine (Cloridrate of (+)-(S)-
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