Abstract
Antidepressant and Antipsychotic-like Activity of the Ethanolic Extract of the Leaves of Maytenus macrocarpa
Highlights
Maytenus macrocarpa (Chuchuhuasi) is an Amazonian Peruvian traditional plant, traditionally used as anti-inflammatory, antipyretic, antihemorrhagic and antidiarrheic agent
The aim of this study was to determinate the antidepressant and antipsychotic-like activity of the ethanolic extract of Maytenus macrocarpa. It was used the ethanolic extract of the leaves of Maytenus macrocarpa (EELMM) in female mice at the experimental model of the Forced Swim Test described by Porsolt
It was demonstrated the antidepressant-like activity of the ethanolic extract of the leaves of Maytenus macrocarpa with a dose of 500 mg/kg and an antipsychotic-like activity with a dose of 1000 mg/kg
Summary
Maytenus macrocarpa (Chuchuhuasi) is an Amazonian Peruvian traditional plant, traditionally used as anti-inflammatory, antipyretic, antihemorrhagic and antidiarrheic agent. It is traditionally used for its analgesic, antipyretic, antidiarrheic and antihemorrhagic at postpartum properties among others.[2,4,5] Chuchuhuasi is part of a selected group of Peruvian plants named master plants, as ayahuasca, coca, among other. These plants are used to heal a person by taking it to high levels of the consciousness, coming into contact with the spiritual world; this is why these plants are probably attributed effects at central nervous systems as psychotropic and hallucinogens.[6,7,8,9]
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