Anti-Depressant Activity of Aqueous Leaf Extract of Pergularia daemia in In-Vivo Animal Models

Abstract

The plant leaf of Pergulariadaemia was used for management of depressive state in various traditional system of medicine like Ayurveda, Unani and Siddha. In the absence of substantial pharmacological data, the present study attempts to study the antidepressant activity of Pergulariademia aqueous extract, by using forced swim test and tail suspension test. Animals were grouped into four treatment groups (n=4) and injected with normal saline (control), imipramine-10 mg/kg (Standard drug), Pergulariadaemia aqueous extract 200 and 400 mg/kg (test drug) orally. Duration of immobility was observed for tail suspension test and forced swim test and compared with control (negative control) and imipramine (positive control). The results showed that in both TST and FST, the aqueous extract of Pergulariadaemia at dose of 200 and 400 mg/kg significantly reduced immobility time (p<0.01) in acute studies and further reduced in chronic studies. However, the effect was increased in swimming (P<0.01) and insignificant change in climbing in acute studies and increased in duration of swimming and climbing (P<0.05 and P<0.01) in chronic studies in FST. The aqueous extract of Pergulariadaemia possesses dose dependent antidepressant effect. Current studies confirm the claimed antidepressant activity in selected doses (200 and 400 mg/kg). Keywords: Antidepressant, Pergulariadaemia, tail suspension test, forced swim test, neurotransmitters Cite this Article Iswar Hazarika. Anti-Depressant activity of aqueous leaf extract of Pergularia Daemia in In-Vivo animal models. Research and Reviews: Journal of Neuroscience . 2015; 5(3): 21–26p