Abstract
The aim of this study was to investigate the potential antidepressive effect of aqueous extract of Phaseolus vulgaris (AEPV) and its mechanism of the antidepressant-like action in validated models of depression. Force swim test (FST) in rats and 5-hydroxytryptophan (5-HTP)-induced head-twitch responses (HTRs) in mice were performed to assess the potential antidepressant-like activity of AEPV. Oral administration of AEPV markedly reduced the duration of immobility during the FST in dose-dependent (250 and 500 mg/kg) manner and these effects were similar to that of imipramine. However, AEPV at a dose of 500 mg/kg, p.o. potentiate 5-HTP-induced HTR in mice, as similar to that of fluoxetine (FLU). In conclusion, this study depicts the antidepressant-like effect of AEPV in animal models of depression.
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