Abstract
Antidepressives have shown historically their utility in treatment of depression, confirmed not only in clinical studies, but also in the day-to-day medical practice. The treatment of depression is measured by reduction of suicide attempts and mortality associated to suicide, both conditions generally present in this disorder. During the last years, FDA has not allowed the use of antidepressives in children and adolescents due to increase in suicidal ideation, a fact observed in some studies with methodological incongruences and lack of significant differences with placebo. It is not possible to attribute direct responsibility to antidepressives because depression includes the diagnostic criteria of suicidal ideation reduction of suicide rate supports the effectiveness of these medications.
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