Abstract
AbstractDue to the harmful impact of preformed anti-HLA-A/B/DR/DQ DSA (Donor Specific Antibody) on kidney transplantation, organ allocation systems take these antibodies into account in the transplant decision. Nevertheless, more and more studies point to the deleterious role of preformed anti-Cw and anti-DP antibodies as well.Indeed, it appears from the literature that the presence of anti-Cw and antiDP DSA adversely affects the survival of the graft.These DSA are incriminated in the occurrence of graft rejection, with a correlation of their MFI (Mean Fluorescence Intensity) thresholds with their pathological potential. However, no consensus has yet been established.We present two cases of patients candidates for kidney transplantation, for whom the presence of anti-Cw and anti-DP DSA hampered access to the transplant.This strategy, which takes these DSAs into account in the renal transplant decision, requires carrying out the HLA-Cw and HLA-DP typings of the donor as soon as the potential recipient presents an anti-Cw and/or anti-DP immunization.
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