Abstract
The purpose of this study was to determine whether stearoylethanolamine (SEA), a signaling lipid substance with cannabimimetic effects, would be effective against pentylenetetrazole induced seizure. In the pentylenetetrazole (60 mg/kg) model of acute seizure, the effects of SEA in doses of 1 and 10 mg/kg were evaluated. The vehicle for SEA consisted of alcohol, tween 80 and saline (5:5:90, vol. % accordingly) and was proved to have no effect on the seizure onset and severity by itself. Severity of seizure was estimated by Racine’s scale. It was shown that preliminary i.p. injection of SEA in a dose of 1 mg/kg made no effect on the latency before first convulsion and overall seizures severity. Nonetheless, SEA in a dose of 10 mg/kg increased the latent period before the seizure onset by 58 % and decreased the seizure severity according to Racine’s scale by 27 %. Thus, SEA produces the antiepileptic effect, but does not completely suppress seizures. The mechanism of action of SEA remains to be defined.
Highlights
The purpose of this study was to determine whether stearoylethanolamine (SEA), a signaling lipid substance with cannabimimetic effects, would be effective against pentylenetetrazole induced seizure
The vehicle for SEA consisted of alcohol, tween 80 and saline (5:5:90, vol % ) and was proved to have no effect on the seizure onset and severity by itself
It was shown that preliminary i.p. injection of SEA in a dose of 1 mg/kg made no effect on the latency before first convulsion and overall seizures severity
Summary
В модели эпилептического припадка, вызванного инъекцией пентилентетразола (60 мг/кг), оценивали эффекты SEA в дозах 1 и 10 мг/кг. Установлено, что заблаговременная (за 30 мин) внутрибрюшинная инъекция SEA в дозе 1 мг/кг не вызывает достоверных изменений в формировании тонико-клонических припадков, вызванных пентилентетразолом. В то же время в дозе 10 мг/кг SEA увеличивает латентный период до наступления первого приступа на 58 %, а также снижает общую выраженность судорожной активности по шкале Расина на 27 %.
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