Abstract
Eighteen newer methaqualone analogs, i.e., chlorostrylquinazolones, were tested for their anticonvulsant and monoamine oxidase inhibitory properties. Quinazolones possessing hydrazide moiety were found to be more potent inhibitors than their corresponding precursor esters. In this study 6-chloro-3-(4-benzhydrazide)-2-(2-chlorostyryl)-4-quinazolones was found to possess maximum anticonvulsant activity and provided 60% protection against pentylenetetrazol-induced convulsions in mice while 6-chloro-3-(4-benzhydrazide)-2-(2-hydroxy-5-nitrostyryl)-4-quinazolone caused maximum inhibition of 88% of the activity of rat brain monoamine oxidase. No direct correlationship could be observed between monoamine oxidase inhibitory and anticonvulsant properties of these substituted quinazolones.
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