Abstract
Certain anticonvulsant sulfur compounds which were mentioned briefly in a previous publication1have been investigated in more detail. Interest in the possible anticonvulsant properties of the sulfoxides and sulfones was suggested by their structural similarity to the ketones, which had been found to have pronounced anticonvulsant activity.2These structural relationships are illustrated by the formula for ethyl phenyl ketone (propiophenone), ethyl phenyl sulfoxide and ethyl phenyl sulfone: The sulfoxides and sulfones possess more desirable physical properties than the alkylaryl sulfides, which were also observed to possess anticonvulsant activity. Additional study of homologous sulfides was discontinued because of their undesirable odor and unsavory taste. Our interest in the sulfones was further stimulated by the observation that dimethyl sulfone occurs naturally. Thus, Pfiffner and North3isolated it from adrenal gland extracts, while Ruzicka and coworkers4reported its isolation from dried cattle blood. Although this sulfone could arise from
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