Abstract
The anticonvulsant activities of Glauciumvitellinum extract and alkaloid sub-fraction were assessed in pentylenetetrazole (PTZ)-induced convulsion and maximal electroshock test (MEST) in mice, with Diazepam as standard drug. While mechanistic studies were conducted using flumazenil, a GABAA-benzodiazepine receptorcomplex site antagonist.The extract and the alkaloid sub-fractionproduced protectionagainst convulsion at100, 200, 400 mg/kg and 50 mg/kg respectively compared with protection with benzodiazepine.The mean onset and percentage protection against convulsion in extract/sub-fraction-treated mice werereduced by flumazenil. We also showed that G. vitellinum extract (200 mg/kg) exhibited inhibition of the tonic convulsion induced by MES and decreased mortality rate.These results suggest that G. vitellinumpossesses biologically active constituent(s) mainly belong to isoquinoline alkaloid group that haveanticonvulsant activity which supports the ethnomedicinal claims of the use of the plant in the management of seizure.
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