Abstract
To study the anticonvulsant effects of gabapentin (GBP) in immature animals. Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats. Animals pretreated with GBP (15, 30, or 60 mg/kg i.p.) were compared with controls. The incidence and latency of two types of seizures [minimal (i.e., clonic)] and generalized tonic-clonic (GTCS) were recorded, and seizure severity was scored. GBP suppressed or at least restricted the tonic phase of GTCS at all the developmental stages studied. In addition, minimal seizures were suppressed in 18-day-old rats. Both effects exhibited a tendency to a U-shaped dose-response curve. Anticonvulsant effects of GBP were demonstrated in immature and in adult rats.
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