Abstract
The experiment was carried out with 150 Cobb broiler chickens divided into 3 groups with 50 birds each. The groups of infected chickens orally received 1ml of inoculum containing 3x103 Eimeria acervulina sporulated oocysts at 12 days of age. Group 1 was kept as a positive control with infected non-medicated birds, group 2 was medicated with diclazuril (1%) with a dose of 1mL/4 L of drinking water for 2 successive days, 5 days after infection, while group 3 was kept as negative control with non-infected and non-medicated birds. Oocysts count per gram of feces, score of macroscopic intestinal lesions and weight gain were evaluated. The group treated with diclazuril showed significant and satisfactory improvement in the assessment criteria when compared to the infected non-medicated group. The results revealed more reduction in the total oocyst count and intestinal lesion score in the medicated than in the infected non-treated group. The results confirmed that (1%) liquid diclazuril is effective to control Eimeria infection.
Highlights
Coccidiosis is a parasitic disease that causes the greatest economic losses to the poultry industry worldwide, which were estimated at $3 billion dollars annually (Dalloul and Lillehoj, 2006)
New formulations of water soluble diclazuril for administration in drinking water were introduced in many parts of the world, and few studies were conducted to study its efficacy in the prevention and control of chicken coccidiosis (El-Banna et al, 2005)
BIOVET provided the 12-day-old broilers individually inoculated with oral doses of 3x103 E. acervulina oocysts, strain Ea3LP8a (EMBRAPA), in a volume of 0.5mL of inoculum per bird using a 1mL sterile syringe coupled to a cannula to access the esophagus
Summary
Coccidiosis is a parasitic disease that causes the greatest economic losses to the poultry industry worldwide, which were estimated at $3 billion dollars annually (Dalloul and Lillehoj, 2006). The usual strategy to control coccidiosis in broilers is based on the use of anticoccidial drugs (Conway and Mckenzie, 1991). The prophylactic anticoccidial efficacy of diclazuril in feed was extensively studied in chickens (Conway et al, 2002; Awaad et al, 2003). The aim of this study was to evaluate the efficacy of a soluble formulation of diclazuril in the control of E. acervulina oocysts administered for only two days. This single experiment with the soluble form of diclazuril might be useful for broiler producers where the feed treatment is difficult or not possible
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