Abstract
Aims: To improve the side effects caused by sodium citrate (Na<sub>3</sub>Cit), the anticoagulant effects of diethyl citrate (Et<sub>2</sub>Cit) were investigated. Methods: The in vitro anticoagulant effects and dissociation capacity of the chelate of Et<sub>2</sub>Cit with calcium ions were compared with those of Na<sub>3</sub>Cit in rabbits. Results: The activated coagulation time test showed that blood clotting time exceeded 1,200 s when the concentrations of Et<sub>2</sub>Cit and Na<sub>3</sub>Cit were greater than 87.2 and 8.72 mmol/l, respectively. The concentrations of free calcium ions in blood c(Ca<sup>2+</sup>) were reduced when Et<sub>2</sub>Cit was injected into the rabbits. Conclusions: Et<sub>2</sub>Cit reduces the concentration of ionized Ca<sup>2+</sup> in blood and has anticoagulant effects. The dissociation of the chelate of Et<sub>2</sub>Cit with Ca<sup>2+</sup> was faster than that of Na<sub>3</sub>Cit with Ca<sup>2+</sup> within 10 min after injection. The recovery speed of blood calcium concentration with Et<sub>2</sub>Cit was more rapid than that with Na<sub>3</sub>Cit. The findings show that Et<sub>2</sub>Cit prevents hypocalcemia.
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