Anticoagulation effect of LMWH combined with warfarin on intracranial venous sinus thrombosis at early stage

Abstract

Objective To investigate the anticoagulation effect of warfarin combined with low molecular weight heparin (LMWH) on cerebral venous sinus thrombosis(CVST) at early stage. Methods From January 2011 to January 2015, 48 patients with intracranial venous sinus thrombosis were randomly divided into the warfarin group and the combination group, with 24 cases in each group. The patients in the warfarin group were treated with oral warfarin 2.5 mg/times, 2 times/d, and the patients in the combination group were treated with oral warfarin 2.5mg/times and low molecular weight heparin treatment. The clinical efficacy, the recovery of venous sinus, and prothrombin time(Pt), thrombin time and thrombin time(TT) and activated partial extra transportation charges time(APTT), fibrinogen(FBG) of the two groups were compared. Results The clinical efficacy in the combination group (87.50%) was higher than that of the warfarin group (62.50%), the difference was significant (P<0.05). After treatment, the venous sinus recovery rate in the combination group (83.33%) was higher than that in the warfarin group(54.17%), the difference was significant (P<0.05). After treatment, the levels of PT, FBG, TT, APTT significantly improved compared with before treatment, the levels of PT, TT, APTT increased significantly, the level of FBG decreased significantly, and the levels of PT, APTT and FBG in the combination group were superior to those in the warfarin group, the differences were significant (P<0.05). Conclusions The anticoagulation effect of warfarin combined with LMWH on CVST at early stage is remarkable, it can effectively restore recanalization of intracranial venous sinus thrombosis, improve the levels of PT, FBG, TT and APTT, so it is worthy to be popularized. Key words: Warfarin; Intracranial venous sinus thrombosis; Early anti-coagulation; Low molecular weight heparin; Curative effect