Abstract
WHEN a blood vessel has been severed the prompt coagulation of blood is an essential safeguard against fatal hemorrhage. Yet the same defense mechanism may itself threaten life through the formation and propagation of an intravascular clot. Although heparin had been employed successfully as early as 1935 to prevent intravascular clotting, its brief duration of action and high cost discouraged general use. The discovery of Dicumarol stimulated enormous interest in the anticoagulant drugs and the ability of these agents to prevent thrombosis and embolism has now been established beyond doubt. It is equally well established that the careless administration of . . .
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