Abstract
Safety and outcome of anticoagulant therapy in neonates and children with cerebral sinovenous thrombosis (CSVT) were determined in a study at the Hospital for Sick Children and Toronto Western Hospital, Ontario, Canada.
Highlights
Safety and outcome of anticoagulant therapy in neonates and children with cerebral sinovenous thrombosis (CSVT) were determined in a study at the Hospital for Sick Children and Toronto Western Hospital, Ontario, Canada
Major hemorrhage occurred in 6% (6/99) of treated patients; they were all nonfatal and clinical outcome was favorable in 50%
Follow-up imaging showed thrombus propagation in 11/57 neonates (10/35 [28%] without and 1/22 [4%] with anticoagulant therapy (p=0.037)) and in 10/63 children (7/19 [37%] without and 3/44 [7%] with anticoagulant [p=0.006])
Summary
Safety and outcome of anticoagulant therapy in neonates and children with cerebral sinovenous thrombosis (CSVT) were determined in a study at the Hospital for Sick Children and Toronto Western Hospital, Ontario, Canada. Low vitamin D levels are associated with an increased relapse rate in pediatric-onset multiple sclerosis. Relapse rate in pediatric-onset is significantly higher than that in adult-onset cases (Gorman MP et al Arch Neurol 2009;66:54-59). Mean age of the patients in the above study at time of blood collection was 15 years +/- SD3.
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