Abstract

BackgroundThe indications for warfarin treatment in primary health care are increasing. An undertreatment with warfarin is reported in the prevention of embolic stroke in patients with chronic atrial fibrillation, and can be suspected for other indications. Information on the prevalence and incidence of diseases treated with warfarin would reveal useful data for audits concerning management of anticoagulant treatment. We aimed to assess warfarin treatment in primary health care with regard to prevalence, incidence, treatment diagnosis and patient characteristics.MethodsA one-year retrospective study of electronic patient records up to May 2000 in primary health care in Stockholm, Sweden. Five primary health care centres with a registered population of 75 146. Main outcome measures were prevalence, incidence and treatment diagnosis.ResultsFive hundred and seven patients, mean age 71.9 years, were on warfarin treatment. The prevalence was 0.67% (age-adjusted 0.75%), and it was significantly higher for men (0.78%) than for women (0.58%) (p = 0.01). In the age group 75–84 years the prevalence was 4.54%. The most prevalent treatment diagnosis was chronic atrial fibrillation (0.28%), which was more predominant for males (p = 0.02), followed by cerebrovascular disease (0.13%) and deep venous thrombosis (0.13%). The yearly incidence of warfarin treatment was 0.17%, with chronic atrial fibrillation as the predominant treatment diagnosis.ConclusionWarfarin treatment in primary health care is prevalent among the elderly. Chronic atrial fibrillation is the main treatment diagnosis. There is a gender difference favouring men in general and chronic atrial fibrillation as the treatment diagnosis.

Highlights

  • The indications for warfarin treatment in primary health care are increasing

  • I.e. vitamin K antagonists, have been shown in well-designed clinical trials to have antithrombotic effectiveness in a variety of disorders and conditions. They are effective in the prevention of venous thromboembolism, thrombosis on heart valve prostheses, embolic stroke in patients with chronic atrial fibrillation (CAF) and cerebrovascular disease [1], in patients with pulmonary embolism [2], and as secondary prophylaxis after myocardial infarction [3]

  • It is well known that efficacy in clinical trials may be a poor guide to effectiveness in everyday clinical practice, and undertreatment with warfarin is reported for CAF [6], and can be suspected for other indications

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Summary

Introduction

The indications for warfarin treatment in primary health care are increasing. An undertreatment with warfarin is reported in the prevention of embolic stroke in patients with chronic atrial fibrillation, and can be suspected for other indications. Information on the prevalence and incidence of diseases treated with warfarin would reveal useful data for audits concerning management of anticoagulant treatment. I.e. vitamin K antagonists, have been shown in well-designed clinical trials to have antithrombotic effectiveness in a variety of disorders and conditions. They are effective in the prevention of venous thromboembolism, thrombosis on heart valve prostheses, embolic stroke in patients with chronic atrial fibrillation (CAF) and cerebrovascular disease [1], in patients with pulmonary embolism [2], and as secondary prophylaxis after myocardial infarction [3]. Information on the occurrence (i.e. prevalence and incidence) of these diseases would reveal useful data for audits concerning management of anticoagulant treatment.

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