Abstract
Anticoagulant peptides obtained from human fibrinogen degradation products by plasmin have been studied. These peptides caused a siginificant prolongation of the plasma prothrombin time and partial thromboplastin time of normal plasma. Moreover, they showed an inhibitory effect on factors VIII, IX, XI, and XII in the intrinsic blood coagulation system. It is suggested that they might have feed-back inhibition against these factors and control thromboplastogenesis in blood coagulation, especially in the intrinsic clotting mechanism.
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