Abstract
Anticlastogenic properties of Quercus infectoria galls extract against DMBA induced genotoxicity in bone marrow cells of mice in vivo
Highlights
Quercus infectoria (Q. infectoria) globally is referred as gall oak, traditionally was used as a common medical herbal in postpartum care and treatment of different diseases; the various Quercus species are originated in Iraq, Iran and Turkey, but are widely spread and common in Asia, Europe and North Africa
Toxicity study The toxic effect of QIG aqueous extract was firstly determined in this study; no mortality or great changes in Mitotic index This study focused on bone marrow as a target tissue because it is extremely vascularized and it has high population of very active cells that can be isolated and prepared
The recorded data showed that the Mitotic index value (QIGE= 8.23±0.405) of animals treated with Quercus infectoria galls extract (QIGE) alone with the dose of 2 gm/kg was lower than that of negative control (PBS = 8.93 ± 0.52), but not significant
Summary
Quercus infectoria (Q. infectoria) globally is referred as gall oak, traditionally was used as a common medical herbal in postpartum care and treatment of different diseases; the various Quercus species are originated in Iraq, Iran and Turkey, but are widely spread and common in Asia, Europe and North Africa. The galls of Q. infectoria reported as antidiabetic, and astringent agent [2], antimicrobial activities against viral, bacterial and parasites [3,4,5]. Tannin 50-70%, gallic acid 2-4%, ellagic acid, starch, and sugar are the most common components showed within the galls of Q. infectoria [6]. Tannins (gallotannic acid) is a phenolic compound characterized by its great roles in tissue protection from mutation, antitumor and protecting tissue from oxidation process [2]. Any chemical that or preferentially reduces the frequency of mutations is known as an antimutagen [7]. Different polynuclear aromatic hydrocarbons (PAH) are found to be wildly distributed in the atmosphere environment and have been known to cause cancer [8]
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