Abstract
Though cypermethrin (Cyp) has contributed considerably to human welfare, their adverse effects on non‐target organisms are significant. The lipophilic nature of this pyrethroid exacerbates its toxicity by facilitating rapid access to the various tissues which in turn increase its interaction with the central nervous system, for which pesticides have high affinity. This study was designed to investigate the anticlastogenic and antidyslipidemic effects of Jatropha gossypifolia (JG), alpha‐lipoic acid (αLA) and vitamin C (VC) on plasma lipoprotein fractions in female rats. Eighty female rats were divided into ten groups of eight animals each and treated orally for 30 days. Groups 1 and 2 were given corn oil and cypermetrhin respectively, groups 3,4,5 and 6 were co‐administered with Cyp+JG50 mg/kg, Cyp+JG100 mg/kg, Cyp+αLA50 mg/kg and Cyp+VC50 mg/kg respectively. Groups 7, 8, 9 and 10 were given only JG50 mg/kg, JG100 mg/kg, αLA50 mg/kg and VC50 mg/kg respectively. From this study, cypermethrin administration resulted in an array of dyslipidemia as evidenced by significant increase in the level of cholesterol in plasma (64.05%), vLDL+LDL (571.88%), ovary (313.97%), uterus (147.49%); and triglyceride in plasma (88.69%), vLDL+LDL (71.51%), uterus (27.27%); however, a significant decrease was observed in ovary triglyceride (70.24%). Also, a significant increase was observed in the mean polychromatic erythrocyte (429.00%) compared to the control. Co‐administration with the methanolic leaf extract of JG, αLA and VC was able to attenuate the observed cypermethrin‐induced dyslipidemia and clastogenicity. Toxicological study from this study revealed that the plant extract is therapeutically safe for consumption at the doses under investigation. It can thus be concluded that the methanolic extract of Jatropha gossypifolia leaf could help regulate the dyslipidemic effect of cypermethrin on lipid parameters in organs and plasma lipoprotein fractions. The anticlastogenic effect of the plant could also be linked to the various phytoconstituents embedded in the plant.
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