Abstract
In vitro , methamidophos was found to be a moderate inhibitor o-~ both insect and mammalian cholinesterases compared to paraoxon, a very strong inhibitor (Hussain et al. 1984). This raises the question as to its mode of action in vivo where severe cholinesterase inhibition was observed in insects and manmals. Two mechanis~s have been put forward. Kao and Fukuto (1977) have proposed that the mode of action of methamidophos may be due to direct inhibition of the cholinesterase in vivo. Because of the stability of methamidophos, inhibition is prolonged. Eto et al. (1977) have suggested another mechanism, that methamidophos may be activated to its sulfoxide which is a much more potent cholinesterase inhibitor. This activated metabolite is unstable and has not been isolated by the researchers.
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